Effect of tight glucose control with insulin on the thyroid axis of critically ill children and its relation with outcome.

ABSTRACT:

Context

Tight glucose control (TGC) to normal-for-age fasting blood glucose levels reduced morbidity and mortality in surgical adult and pediatric intensive care unit (ICU) patients. In adults, TGC did not affect the illness-induced alterations in thyroid hormones. With better feeding in children than in adult patients, we hypothesized that TGC in pediatric ICU patients reactivates the thyroid axis.

Objective

The aim of this study was to assess the impact of TGC on the thyroid axis in pediatric ICU patients and to investigate how these changes affect the TGC outcome benefit.

Design and patients

We conducted a preplanned analysis of all patients not treated with thyroid hormone, dopamine, or corticosteroids who were included in a randomized controlled trial on TGC (n=7

SUBMITTER: Gielen M 

PROVIDER: S-EPMC3462949 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature