Biosynthesis of piperazic acid via N5-hydroxy-ornithine in Kutzneria spp. 744.

ABSTRACT: Which came first? We have investigated the biosynthesis of the piperazic acid (Piz) building blocks in the kutzneride family of metabolites. The flavin-dependent oxygenase KtzI was shown to convert ornithine to N(5)-OH-Orn. LC-MS/MS showed (13)C(5)-labeled versions of these two amino acids to be direct precursors of piperazic acid in vivo.

SUBMITTER: Neumann CS 

PROVIDER: S-EPMC3463134 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature