Base of the measles virus fusion trimer head receives the signal that triggers membrane fusion.

ABSTRACT: The measles virus (MV) fusion (F) protein trimer executes membrane fusion after receiving a signal elicited by receptor binding to the hemagglutinin (H) tetramer. Where and how this signal is received is understood neither for MV nor for other paramyxoviruses. Because only the prefusion structure of the parainfluenza virus 5 (PIV5) F-trimer is available, to study signal receipt by the MV F-trimer, we generated and energy-refined a homology model. We used two approaches to predict surface residues of the model interacting with other proteins. Both approaches measured interface propensity values for patches of residues. The second approach identified, in addition, individual residues based on the conservation of physical chemical properties among F-proteins. Altogether, about 50 candidate in

SUBMITTER: Apte-Sengupta S 

PROVIDER: S-EPMC3463363 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature