Sca-1 knockout impairs myocardial and cardiac progenitor cell function.

ABSTRACT:

Rationale

Cardiac progenitor cells are important for maintenance of myocardial structure and function, but molecular mechanisms governing these progenitor cells remain obscure and require elucidation to enhance regenerative therapeutic approaches.

Objective

To understand consequences of stem cell antigen-1 (Sca-1) deletion on functional properties of c-kit+ cardiac progenitor cells and myocardial performance using a Sca-1 knock-out/green fluorescent protein knock-in reporter mouse (ScaKI).

Methods and results

Genetic deletion of Sca-1 results in early-onset cardiac contractile deficiency as determined by echocardiography and hemodynamics as well as age-associated hypertrophy. Resident cardiac progenitor cells in ScaKI mice do not respond to pathological damage in vivo

SUBMITTER: Bailey B 

PROVIDER: S-EPMC3463406 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature