Stabilization of the murine gut microbiome following weaning.

ABSTRACT: Ecologists hypothesize that community structure and stability affect productivity, sensitivity to invasion and extinction, and resilience and resistance to perturbations. Viewed in the context of the gut microbiome, the stability of the gut community is important for understanding the effects of antibiotics, diet change and other perturbations on host health and colonization resistance. Here we describe the dynamics of a self-contained community, the murine gut microbiome. Using 16S rRNA gene sequencing of fecal samples collected daily from individual mice, we characterized the community membership and structure to determine whether there were significant changes in the gut community during the first year of life. Based on analysis of molecular variance, we observed two community states. T

SUBMITTER: Schloss PD 

PROVIDER: S-EPMC3463496 | biostudies-literature | 2012 Jul-Aug

REPOSITORIES: biostudies-literature