Of mice and men: divergence of gene expression patterns in kidney.

ABSTRACT: Since the development of methods for homologous gene recombination, mouse models have played a central role in research in renal pathophysiology. However, many published and unpublished results show that mice with genetic changes mimicking human pathogenic mutations do not display the human phenotype. These functional differences may stem from differences in gene expression between mouse and human kidneys. However, large scale comparison of gene expression networks revealed conservation of gene expression among a large panel of human and mouse tissues including kidneys. Because renal functions result from the spatial integration of elementary processes originating in the glomerulus and the successive segments constituting the nephron, we hypothesized that differences in gene expression pro

SUBMITTER: Cheval L 

PROVIDER: S-EPMC3463552 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature