Roles of spatial parameters on the oscillation of nuclear NF-κB: computer simulations of a 3D spherical cell.

ABSTRACT: Transcription factor NF-κB resides in the cytoplasm and translocates to the nucleus by application of extracellular stimuli. It is known that the nuclear NF-κB oscillates and different oscillation patterns lead to different gene expression. Nearly forty reports on modeling and simulation of nuclear NF-κB have been published to date. The computational models reported so far are temporal or two-dimensional, and the discussions on spatial parameters have not been involved or limited. Since spatial parameters in cancer cells such as nuclear to cytoplasmic volume (N/C) ratio are different from normal cells, it is important to understand the relationship between oscillation patterns and spatial parameters. Here we report simulations of a 3D computational model for the oscillation of nuclear NF-κ

SUBMITTER: Ohshima D 

PROVIDER: S-EPMC3463570 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature