Relative effects of negative versus positive pressure ventilation depend on applied conditions.

ABSTRACT:

Purpose

Comparisons of negative versus positive pressure ventilation have imperfectly matched the pressure-time profile or the lung volume history, or have incompletely applied in vivo negative pressure to include the complete thoracic wall and abdomen.

Hypothesis

Negative pressure exerts the same pattern of lung distension as positive pressure when the pressure-time and volume history profiles are identical and the application of negative pressure is over the whole lung.

Methods

(1) In isolated (ex vivo) and (2) intact (in vivo) mouse lungs (n = 4/group) (sealed chamber enclosing either the whole lung or whole mouse except for external airway opening), identical and inverse-tidal, square-wave pressure-time profiles were obtained with positive and negative pressure v

SUBMITTER: Engelberts D 

PROVIDER: S-EPMC3463870 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature