Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex.

ABSTRACT:

Background

Endocannabinoids provide control over cortical neurotransmission. We investigated the developmental expression of key genes in the endocannabinoid system across human postnatal life and determined whether they correspond to the development of markers for inhibitory interneurons, which shape cortical development. We used microarray with qPCR validation and in situ hybridisation to quantify mRNA for the central endocannabinoid receptor CB(1)R, endocannabinoid synthetic enzymes (DAGLα for 2-arachidonylglycerol [2-AG] and NAPE-PLD for anandamide), and inactivating enzymes (MGL and ABHD6 for 2-AG and FAAH for anandamide) in human dorsolateral prefrontal cortex (39 days - 49 years).

Results

CB(1)R mRNA decreases until adulthood, particularly in layer II, after peaking b

SUBMITTER: Long LE 

PROVIDER: S-EPMC3464170 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature