Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control.

ABSTRACT:

Background

Effective tight glycemic control (TGC) can improve outcomes in critical care patients, but it is difficult to achieve consistently. Insulin sensitivity defines the metabolic balance between insulin concentration and insulin-mediated glucose disposal. Hence, variability of insulin sensitivity can cause variable glycemia. This study quantifies and compares the daily evolution of insulin sensitivity level and variability for critical care patients receiving TGC.

Methods

This is a retrospective analysis of data from the SPRINT TGC study involving patients admitted to a mixed medical-surgical ICU between August 2005 and May 2007. Only patients who commenced TGC within 12 hours of ICU admission and spent at least 24 hours on the SPRINT protocol were included (N = 164).

SUBMITTER: Pretty CG 

PROVIDER: S-EPMC3464183 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature