Default network modulation and large-scale network interactivity in healthy young and old adults.

ABSTRACT: We investigated age-related changes in default, attention, and control network activity and their interactions in young and old adults. Brain activity during autobiographical and visuospatial planning was assessed using multivariate analysis and with intrinsic connectivity networks as regions of interest. In both groups, autobiographical planning engaged the default network while visuospatial planning engaged the attention network, consistent with a competition between the domains of internalized and externalized cognition. The control network was engaged for both planning tasks. In young subjects, the control network coupled with the default network during autobiographical planning and with the attention network during visuospatial planning. In old subjects, default-to-control network cou

SUBMITTER: Spreng RN 

PROVIDER: S-EPMC3464415 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature