Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes.

ABSTRACT:

Background

Listeria monocytogenes is a food-borne pathogen that causes infections with a high-mortality rate and has served as an invaluable model for intracellular parasitism. Here, we report complete genome sequences for two L. monocytogenes strains belonging to serotype 4a (L99) and 4b (CLIP80459), and transcriptomes of representative strains from lineages I, II, and III, thereby permitting in-depth comparison of genome- and transcriptome -based data from three lineages of L. monocytogenes. Lineage III, represented by the 4a L99 genome is known to contain strains less virulent for humans.

Results

The genome analysis of the weakly pathogenic L99 serotype 4a provides extensive evidence of virulence gene decay, including loss of several important surface proteins. The 4b CLI

SUBMITTER: Hain T 

PROVIDER: S-EPMC3464598 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature