Elevated type I interferon-like activity in a subset of multiple sclerosis patients: molecular basis and clinical relevance.

ABSTRACT:

Background

A subset of patients with multiple sclerosis (MS) shows an increased endogenous IFN-like activity before initiation of IFN-beta treatment. The molecular basis of this phenomenon and its relevance to predict individual therapy outcomes are not yet fully understood. We studied the expression patterns of these patients, the prognostic value of an elevated IFN-like activity, and the gene regulatory effects of exogenously administered IFN-beta.

Methods

Microarray gene expression profiling was performed for 61 MS patients using peripheral blood mononuclear cells obtained before and after 1 month of IFN-beta therapy. Expression levels of genes involved in pathways either inducing or being activated by IFN-beta were compared between patients with high (MX1(high) cohort) a

SUBMITTER: Hundeshagen A 

PROVIDER: S-EPMC3464734 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature