Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population.

ABSTRACT:

Background

Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorphisms and their association with ischemic stroke in a Chinese Han population.

Methods

A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes. We tested the genotype-stroke association with logistic regression model.

Results

We found two single nucleotide polymorphisms (SNPs) in CCL11 were associated with ischemic stroke. After adjusting for multiple testing using false discovery rate (FDR) with a 0.20 cut-off point, CCL11 rs47

SUBMITTER: Zhao N 

PROVIDER: S-EPMC3464807 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature