Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.

ABSTRACT:

Purpose

The complement system is closely linked to the pathogenesis of AMD. Several complement genes are expressed in RPE, and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers increased risk of developing AMD. Because the mechanisms by which changes in the function of CFH influence development of AMD are unclear, we examined ocular complement expression as a consequence of age in control and CFH null mutant mice.

Methods

Gene expression in neuroretinas and RPE/choroid from young and aged WT and Cfh(-/-) C57BL/6J mice was analyzed by microarrays. Expression of a wide range of complement genes was compared with expression in liver.

Results

An age-associated increased expression of complement, particularly C1q, C3,

SUBMITTER: Faber C 

PROVIDER: S-EPMC3465015 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature