Pilot study of a model-based approach to blood glucose control in very-low-birthweight neonates.

ABSTRACT:

Background

Hyperglycemia often occurs in premature, very low birthweight infants (VLBW) due to immaturity of endogenous regulatory systems and the stress of their condition. Hyperglycemia in neonates has been linked to increased morbidities and mortality and occurs at increasing rates with decreasing birthweight. In this cohort, the emerging use of insulin to manage hyperglycemia has carried a significant risk of hypoglycemia. The efficacy of blood glucose control using a computer metabolic system model to determine insulin infusion rates was assessed in very-low-birth-weight infants.

Methods

Initial short-term 24-hour trials were performed on 8 VLBW infants with hyperglycemia followed by long-term trials of several days performed on 22 infants. Median birthweight was 745 g

SUBMITTER: Le Compte AJ 

PROVIDER: S-EPMC3465220 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature