Profiling microRNAs in lung tissue from pigs infected with Actinobacillus pleuropneumoniae.

ABSTRACT:

Background

MicroRNAs (miRNAs) are a class of non-protein-coding genes that play a crucial regulatory role in mammalian development and disease. Whereas a large number of miRNAs have been annotated at the structural level during the latest years, functional annotation is sparse. Actinobacillus pleuropneumoniae (APP) causes serious lung infections in pigs. Severe damage to the lungs, in many cases deadly, is caused by toxins released by the bacterium and to some degree by host mediated tissue damage. However, understanding of the role of microRNAs in the course of this infectious disease in porcine is still very limited.

Results

In this study, the RNA extracted from visually unaffected and necrotic tissue from pigs infected with Actinobacillus pleuropneumoniae was subjected to

SUBMITTER: Podolska A 

PROVIDER: S-EPMC3465251 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature