Sex-specific differences in effect size estimates at established complex trait loci.

ABSTRACT:

Background

Genetic differences between men and women may contribute to sex differences in prevalence and progression of many common complex diseases. Using the WTCCC GWAS, we analysed whether there are sex-specific differences in effect size estimates at 142 established loci for seven complex diseases: rheumatoid arthritis, type 1 diabetes (T1D), Crohn's disease, type 2 diabetes (T2D), hypertension, coronary artery disease and bipolar disorder.

Methods

For each Single nucleotide polymorphism (SNP), we calculated the per-allele odds ratio for each sex and the relative odds ratios (RORs; the effect size is higher in men with ROR greater than one). RORs were then meta-analysed across loci within each disease and across diseases.

Results

For each disease, summary RORs wer

SUBMITTER: Orozco G 

PROVIDER: S-EPMC3465768 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature