Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen.

ABSTRACT: The survival of all microbes depends upon their ability to respond to environmental challenges. To establish infection, pathogens such as Candida albicans must mount effective stress responses to counter host defences while adapting to dynamic changes in nutrient status within host niches. Studies of C. albicans stress adaptation have generally been performed on glucose-grown cells, leaving the effects of alternative carbon sources upon stress resistance largely unexplored. We have shown that growth on alternative carbon sources, such as lactate, strongly influence the resistance of C. albicans to antifungal drugs, osmotic and cell wall stresses. Similar trends were observed in clinical isolates and other pathogenic Candida species. The increased stress resistance of C. albicans was not de

SUBMITTER: Ene IV 

PROVIDER: S-EPMC3465787 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature