Variations in the vascular endothelial growth factor pathway predict pulmonary complications.

ABSTRACT:

Background

Clinical factors predicting pulmonary complications after lung resection have been well described, whereas the role of genetics is unknown. The vascular endothelial growth factor (VEGF) signaling pathway has been linked to acute lung injury. We hypothesized that genetic variations in this pathway may be associated with postoperative pulmonary complications after lung resection.

Methods

One hundred ninety-six single nucleotide polymorphisms (SNPs) in 17 genes in the VEGF pathway were genotyped in a discovery set of 264 patients and a replication set of 264 patients who underwent lobectomy for lung cancer. Multivariable analysis adjusting for baseline clinical factors was used to identify SNPs associated with pulmonary complications. Cumulative and classification an

SUBMITTER: Kim JY 

PROVIDER: S-EPMC3466075 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature