Nucleosome occupancy at transcription start sites in the human malaria parasite: a hard-wired evolution of virulence?

ABSTRACT: Almost a decade after the publication of the complete sequence of the genome of the human malaria parasite Plasmodium falciparum, the mechanisms involved in gene regulation remain poorly understood. Like other eukaryotic organisms, P. falciparum's genomic DNA organizes into nucleosomes. Nucleosomes are the basic structural units of eukaryotic chromatin and their regulation is known to play a key role in regulation of gene expression. Despite its importance, the relationship between nucleosome positioning and gene regulation in the malaria parasite has only been investigated recently. Using two independent and complementary techniques followed by next-generation high-throughput sequencing, our laboratory recently generated a dynamic atlas of nucleosome-bound and nucleosome-free regions (NFR

SUBMITTER: Ponts N 

PROVIDER: S-EPMC3466077 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature