Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis.

ABSTRACT:

Background

Recent evidence suggests that the effects of certain food additives may be synergistic or additive. Aspartame (ASP) and Monosodium Glutamate (MSG) are ubiquitous food additives with a common moiety: both contain acidic amino acids which can act as neurotransmitters, interacting with NMDA receptors concentrated in areas of the Central Nervous System regulating energy expenditure and conservation. MSG has been shown to promote a neuroendocrine dysfunction when large quantities are administered to mammals during the neonatal period. ASP is a low-calorie dipeptide sweetener found in a wide variety of diet beverages and foods. However, recent reports suggest that ASP may promote weight gain and hyperglycemia in a zebrafish nutritional model.

Methods

We investigated the

SUBMITTER: Collison KS 

PROVIDER: S-EPMC3466134 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature