No biological evidence of XMRV infection in cervical smears from HIV/ HPV positive and negative Kenyan women.

ABSTRACT:

Background

XMRV (xenotropic murine leukaemia virus-related virus) is a gammaretrovirus first discovered in human prostate carcinomas and later linked to chronic fatigue syndrome (CFS). Emerging conflicting data and lack of reproducibility of results within the scientific community has now led to the association of XMRV with CFS being discounted. Indeed the case for an involvement with any human disease has been questioned with the suggestion that XMRV is a laboratory generated recombinant virus. The fact that not all published positive findings can be easily explained as contamination artefacts coupled with the observation that XMRV may have a sexually transmitted mode of infectivity and can be infectious for primates, where it preferential resides in cells of the reproductive trac

SUBMITTER: He X 

PROVIDER: S-EPMC3466230 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature