Towards the improved discovery and design of functional peptides: common features of diverse classes permit generalized prediction of bioactivity.

ABSTRACT: The conventional wisdom is that certain classes of bioactive peptides have specific structural features that endow their particular functions. Accordingly, predictions of bioactivity have focused on particular subgroups, such as antimicrobial peptides. We hypothesized that bioactive peptides may share more general features, and assessed this by contrasting the predictive power of existing antimicrobial predictors as well as a novel general predictor, PeptideRanker, across different classes of peptides.We observed that existing antimicrobial predictors had reasonable predictive power to identify peptides of certain other classes i.e. toxin and venom peptides. We trained two general predictors of peptide bioactivity, one focused on short peptides (4-20 amino acids) and one focused on long pe

SUBMITTER: Mooney C 

PROVIDER: S-EPMC3466233 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature