Paladin is an antiphosphatase that regulates neural crest cell formation and migration.

ABSTRACT: Although a network of transcription factors that specifies neural crest identity in the ectoderm has been defined, expression of neural crest transcription factors does not guarantee eventual migration as a neural crest cell. While much work has gone into determining regulatory relationships within the transcription factor network, the ability of protein modifications like phosphorylation to modulate the function of neural crest regulatory factors and determine when and where they are active also has crucial implications. Paladin, which was previously classified as a phosphatase based on sequence similarity, is expressed in chick neural crest precursors and is maintained throughout their epithelial to mesenchymal transition and migration. Loss of Paladin delays the expression of transcript

SUBMITTER: Roffers-Agarwal J 

PROVIDER: S-EPMC3466348 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature