Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients.

ABSTRACT:

Objective

Sensing of nutrients in the stomach is of crucial importance for the regulation of ingestive behavior especially in the context of metabolic dysfunctions such as obesity. Cells in the gastric mucosa with taste-signaling elements are considered as candidates for sensing the composition of ingested food and consequently modulate gastrointestinal processes. To assess whether obesity might have an impact on gastric chemosensory cells, gastric tissue samples from morbidly obese patients and normal-weight subjects were compared using a reverse transcriptase (RT)-PCR, qPCR and immunohistochemical approach.

Results

Analysis of biopsy tissue samples from human stomach revealed that transcripts for the taste-signaling elements, including the receptor T1R3 involved in the rec

SUBMITTER: Widmayer P 

PROVIDER: S-EPMC3466488 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature