Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan.

ABSTRACT: Our studies revealed that LCA (lithocholic bile acid) extends yeast chronological lifespan if added to growth medium at the time of cell inoculation. We also demonstrated that longevity in chronologically aging yeast is programmed by the level of metabolic capacity and organelle organization that they developed before entering a quiescent state and, thus, that chronological aging in yeast is likely to be the final step of a developmental program progressing through at least one checkpoint prior to entry into quiescence. Here, we investigate how LCA influences longevity and several longevity-defining cellular processes in chronologically aging yeast if added to growth medium at different periods of the lifespan. We found that LCA can extend longevity of yeast under CR (caloric restriction)

SUBMITTER: Burstein MT 

PROVIDER: S-EPMC3466555 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature