Efficacy of eight months of nightly zolpidem: a prospective placebo-controlled study.

ABSTRACT:

Study objectives

To evaluate the long-term (8 months) efficacy of zolpidem in adults with chronic primary insomnia using polysomnography.

Design

Randomized, double-blind, placebo-controlled clinical trial.

Setting

Sleep disorders and research center.

Participants

Healthy participants (n = 91), ages 23-70, meeting DSM-IV-TR criteria for primary insomnia.

Interventions

Nightly zolpidem, 10 mg (5 mg for patients > 60 yrs) or placebo 30 minutes before bedtime for 8 months.

Measurements and results

Polysomnographic sleep parameters and morning subject assessments of sleep on 2 nights in months 1 and 8. Relative to placebo, zolpidem significantly increased overall total sleep time and sleep efficiency, reduced sleep latency and wake after sleep onset wh

SUBMITTER: Randall S 

PROVIDER: S-EPMC3466802 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature