Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children.

ABSTRACT:

Objective

C-type natriuretic peptide (CNP) is a paracrine regulatory factor of the growth plate and plays a key role in endochondral growth. Its amino-terminal propeptide (NTproCNP) is an equimolar product of CNP biosynthesis and is easily measured in plasma. Preliminary studies suggest that NTproCNP levels correlate with height velocity in sheep and children. The objectives of the study were to correlate NTproCNP levels with height velocity and to define the reference range for plasma CNP and NTproCNP across childhood.

Design

This was a prospective, cross-sectional, observational study of healthy children.

Patients

Participants were 258 healthy children between 2 months and 20 years of age.

Measurements

Anthropometrics were obtained and CNP and NTproCNP levels

SUBMITTER: Olney RC 

PROVIDER: S-EPMC3466812 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature