The core regulation module of stress-responsive regulatory networks in yeast.

ABSTRACT: How does a cell respond to numerous external stresses with a limited number of internal molecular components? It has been observed that there are some common responses of yeast to various stresses, but most observations were based on gene-expression profiles and only some part of the common responses were intensively investigated. So far there has been no system-level analysis to identify commonly responsive or regulated genes against various stresses. In this study, we identified a core regulation module (CRM), a commonly involved regulation structure in the regulatory networks of yeast, which cells reuse in response to an array of environmental stresses. We found that regulators in the CRM constitute a hierarchical backbone of the yeast regulatory network and that the CRM is evolutionari

SUBMITTER: Kim D 

PROVIDER: S-EPMC3467048 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature