Effects of nicotine mouth spray on urges to smoke, a randomised clinical trial.

ABSTRACT:

Objective

A new nicotine mouth spray was shown to be an effective stop-smoking treatment. This study was set up to examine the speed with which it relieves urges to smoke, and how it compares with nicotine lozenge in this respect.

Design

Randomised, cross-over trial that compared nicotine mouth spray 2 mg versus nicotine lozenge 2 or 4 mg.

Setting

Clinical pharmacology research unit.

Participants

200 Volunteer smokers who smoked their first cigarette of the day within 30 min of waking.

Interventions

Subjects abstained from smoking the night before the morning they attended the laboratory. Treatment was administered following 5 h of witnessed abstinence.

Primary and secondary outcome measures

Urge to smoke was rated before and at 1, 3, 5, 10, 15, 2

SUBMITTER: Hansson A 

PROVIDER: S-EPMC3467658 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature