FACETS: multi-faceted functional decomposition of protein interaction networks.

ABSTRACT:

Motivation

The availability of large-scale curated protein interaction datasets has given rise to the opportunity to investigate higher level organization and modularity within the protein-protein interaction (PPI) network using graph theoretic analysis. Despite the recent progress, systems level analysis of high-throughput PPIs remains a daunting task because of the amount of data they present. In this article, we propose a novel PPI network decomposition algorithm called FACETS in order to make sense of the deluge of interaction data using Gene Ontology (GO) annotations. FACETS finds not just a single functional decomposition of the PPI network, but a multi-faceted atlas of functional decompositions that portray alternative perspectives of the functional landscape of the underlyi

SUBMITTER: Seah BS 

PROVIDER: S-EPMC3467740 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature