Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial.

ABSTRACT:

Background

Chronic arterial stiffness contributes to the negative health effects of obesity and insulin resistance, which include hypertension, stroke, and increased cardiovascular and all-cause mortality. Weight loss and improved insulin sensitivity are individually associated with improved central arterial stiffness; however, their combined effects on arterial stiffness are poorly understood. The purpose of this study was to determine how insulin levels modify the improvements in arterial stiffness seen with weight loss in overweight and obese young adults.

Methods

To assess the effects of weight loss and decreased fasting insulin on vascular stiffness, we studied 339 participants in the Slow the Adverse Effects of Vascular Aging (SAVE) trial. At study entry, the participa

SUBMITTER: Hughes TM 

PROVIDER: S-EPMC3468408 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature