Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.

ABSTRACT: Pancreatic adenocarcinoma (PAC) is among the most lethal malignancies. While research has implicated multiple genes in disease pathogenesis, identification of therapeutic leads has been difficult and the majority of currently available therapies provide only marginal benefit. To address this issue, our goal was to genomically characterize individual PAC patients to understand the range of aberrations that are occurring in each tumor. Because our understanding of PAC tumorigenesis is limited, evaluation of separate cases may reveal aberrations, that are less common but may provide relevant information on the disease, or that may represent viable therapeutic targets for the patient. We used next generation sequencing to assess global somatic events across 3 PAC patients to characterize each

SUBMITTER: Liang WS 

PROVIDER: S-EPMC3468610 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature