Growth failure and outcome in Rett syndrome: specific growth references.

ABSTRACT:

Objectives

Prominent growth failure typifies Rett syndrome (RTT). Our aims were to 1) develop RTT growth charts for clinical and research settings, 2) compare growth in children with RTT with that of unaffected children, and 3) compare growth patterns among RTT genotypes and phenotypes.

Methods

A cohort of the RTT Rare Diseases Clinical Research Network observational study participants was recruited, and cross-sectional and longitudinal growth data and comprehensive clinical information were collected. A reliability study confirmed interobserver consistency. Reference curves for height, weight, head circumference, and body mass index (BMI), generated using a semiparametric model with goodness-of-fit tests, were compared with normative values using Student's t test adjusted f

SUBMITTER: Tarquinio DC 

PROVIDER: S-EPMC3468773 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature