Assessment of cortical and striatal involvement in 523 Huntington disease brains.

ABSTRACT:

Objective

To evaluate the relationship of striatal involvement in Huntington disease (HD) to involvement in other brain regions, CAG repeat size, onset age, and other factors.

Methods

We examined patterns of neuropathologic involvement in 664 HD brains submitted to the Harvard Brain Tissue Resource Center. Brains with concomitant Alzheimer or Parkinson changes (n = 82), more than 20% missing data (n = 46), incomplete sample submission (n = 12), or CAG repeat less than 36 (n = 1) were excluded, leaving 523 cases. Standardized ratings from 0 (absent) to 4 (severe) of gross and microscopic involvement were performed for 50 regions. Cluster analysis reduced the data to 2 main measures of involvement: striatal and cortical.

Results

The clusters were correlated with each ot

SUBMITTER: Hadzi TC 

PROVIDER: S-EPMC3468776 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature