Racial differences in albuminuria, kidney function, and risk of stroke.

ABSTRACT:

Background

The objective of this study was to examine the joint associations of estimated glomerular filtration rate (eGFR) and urinary albumin excretion with incident stroke in a large national cohort study.

Methods

Associations of urinary albumin to creatinine ratio (ACR) and eGFR with incident stroke were examined in 25,310 participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a prospective study of black and white US adults ≥45 years of age.

Results

A total of 548 incident strokes were observed over a median of 4.7 years of follow-up. Higher ACR values were associated with lower stroke-free survival in both black and white participants. Among black participants, as compared to an ACR <10 mg/g, the hazard ratios of stroke asso

SUBMITTER: Gutierrez OM 

PROVIDER: S-EPMC3468778 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature