Functional modules, structural topology, and optimal activity in metabolic networks.

ABSTRACT: Modular organization in biological networks has been suggested as a natural mechanism by which a cell coordinates its metabolic strategies for evolving and responding to environmental perturbations. To understand how this occurs, there is a need for developing computational schemes that contribute to integration of genomic-scale information and assist investigators in formulating biological hypotheses in a quantitative and systematic fashion. In this work, we combined metabolome data and constraint-based modeling to elucidate the relationships among structural modules, functional organization, and the optimal metabolic phenotype of Rhizobium etli, a bacterium that fixes nitrogen in symbiosis with Phaseolus vulgaris. To experimentally characterize the metabolic phenotype of this microorgani

SUBMITTER: Resendis-Antonio O 

PROVIDER: S-EPMC3469419 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature