Vitamin D and the racial difference in the genotype 1 chronic hepatitis C treatment response.

ABSTRACT:

Background

African Americans with genotype 1 chronic hepatitis C attain a sustained virologic response (SVR) at only approximately one-half the rate of whites after peginterferon and ribavirin treatment. The serum concentration of 25-hydroxyvitamin D [25(OH)D] has recently been established as a predictor of treatment response. Therefore, the low serum concentrations of 25(OH)D found among African Americans may contribute to the low response rate; however, to our knowledge, none of the studies of vitamin D in chronic hepatitis C treatment have included a significant number of black patients.

Objective

The objective was to compare the relation between the 25(OH)D concentration and genotype 1 chronic hepatitis C treatment response in African Americans with that in whites.

De

SUBMITTER: Weintraub SJ 

PROVIDER: S-EPMC3471194 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature