Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps.

ABSTRACT:

Background

The role of well-done meat intake and meat-derived mutagen heterocyclic amine (HCA) exposure in the risk of colorectal neoplasm has been suggested but not yet established.

Objective

With the use of gene-environment interaction analyses, we sought to clarify the association of HCA exposure with colorectal polyp risk.

Design

In a case-control study including 2057 colorectal polyp patients and 3329 controls, we evaluated 16 functional genetic variants to construct an HCA-metabolizing score. To derive dietary HCA-exposure amount, data were collected regarding dietary intake of meat by cooking method and degree of doneness.

Results

A 2-fold elevated risk associated with high red meat intake was found for colorectal polyps or adenomas in subjects with a hi

SUBMITTER: Fu Z 

PROVIDER: S-EPMC3471199 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature