IL-11 is a parietal cell cytokine that induces atrophic gastritis.

ABSTRACT:

Background and aims

IL-is important in gastric damage, mucosal repair and gastric cancer progression. We analysed IL-11 expression in H.pylori infected mouse stomach, the site of gastric IL-11 expression in mice and humans, and the effect of exogenous IL-11 on gastric mucosal homeostasis.

Methods

IL-11 protein was localised in mouse and human stomach. The impact of chronic, exogenous IL-11 on normal mouse stomach was examined histologically and transcriptionally by microarray, confirmed by mRNA and protein analysis. Functional impact of IL-11 on gastric acid secretion was determined.

Results

In mice infected with H.pylori, IL-11 was increased in fundic mucosa with temporal expression similar to IL-1b. IL-11 protein was localised predominantly to parietal cells in mous

SUBMITTER: Howlett M 

PROVIDER: S-EPMC3471558 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature