Genetic variants near PDGFRA are associated with corneal curvature in Australians.

ABSTRACT:

Purpose

Irregularity in the corneal curvature (CC) is highly associated with various eye disorders such as keratoconus and myopia. The sample had limited power to find genomewide significant (5 × 10(-8)) hits but good power for replication. Thus, an attempt was made to test whether alleles in the FRAP1 and PDGFRA genes, recently found to be associated with CC in Asian populations, also influence CC in Australians of North European ancestry. Results of initial genomewide association studies (GWAS) for CC in Australians were also reported.

Methods

Two population-based cohorts of 1788 Australian twins and their families, as well as 1013 individuals from a birth cohort from Western Australia, were genotyped using genomewide arrays. Following separate individual analysis and qual

SUBMITTER: Mishra A 

PROVIDER: S-EPMC3471606 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature