Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer.

ABSTRACT:

Background

Chronic inflammation plays a causal role in gastric tumor initiation. The identification of predictive biomarkers from gastric inflammation to tumorigenesis will help us to distinguish gastric cancer from atrophic gastritis and establish the diagnosis of early-stage gastric cancer. Phospholipase C epsilon 1 (PLCε1) is reported to play a vital role in inflammation and tumorigenesis. This study was aimed to investigate the clinical significance of PLCε1 in the initiation and progression of gastric cancer.

Methodology/principal findings

Firstly, the mRNA and protein expression of PLCε1 were analyzed by reverse transcription-PCR and Western blotting in normal gastric mucous epithelial cell line GES-1 and gastric cancer cell lines AGS, SGC7901, and MGC803. The results

SUBMITTER: Chen J 

PROVIDER: S-EPMC3471869 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature