Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells.

ABSTRACT:

Background

Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway inhibitory genes are silenced by CpG hypermethylation, and other studies have suggested that genistein can demethylate hypermethylated DNA. Genistein is a soy isoflavone with diverse effects on cellular proliferation, survival, and gene expression that suggest it could be a potential therapeutic agent for prostate cancer. We undertook the present study to investigate the effects of genistein on the epigenome of prostate cancer cells and to discover novel combination approaches of other compounds with genistein that might be of translational utility. Here, we have inve

SUBMITTER: Phillip CJ 

PROVIDER: S-EPMC3472186 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature