Iteration method for predicting essential proteins based on orthology and protein-protein interaction networks.

ABSTRACT:

Background

Identification of essential proteins plays a significant role in understanding minimal requirements for the cellular survival and development. Many computational methods have been proposed for predicting essential proteins by using the topological features of protein-protein interaction (PPI) networks. However, most of these methods ignored intrinsic biological meaning of proteins. Moreover, PPI data contains many false positives and false negatives. To overcome these limitations, recently many research groups have started to focus on identification of essential proteins by integrating PPI networks with other biological information. However, none of their methods has widely been acknowledged.

Results

By considering the facts that essential proteins are more evolut

SUBMITTER: Peng W 

PROVIDER: S-EPMC3472210 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature