Yeast glucose pathways converge on the transcriptional regulation of trehalose biosynthesis.

ABSTRACT:

Background

Cellular glucose availability is crucial for the functioning of most biological processes. Our understanding of the glucose regulatory system has been greatly advanced by studying the model organism Saccharomyces cerevisiae, but many aspects of this system remain elusive. To understand the organisation of the glucose regulatory system, we analysed 91 deletion mutants of the different glucose signalling and metabolic pathways in Saccharomyces cerevisiae using DNA microarrays.

Results

In general, the mutations do not induce pathway-specific transcriptional responses. Instead, one main transcriptional response is discerned, which varies in direction to mimic either a high or a low glucose response. Detailed analysis uncovers established and new relationships within a

SUBMITTER: Apweiler E 

PROVIDER: S-EPMC3472246 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature