Brain activation patterns during visual episodic memory processing among first-degree relatives of schizophrenia subjects.

ABSTRACT: Episodic memory deficits are proposed as a potential intermediate phenotype of schizophrenia. We examined deficits in visual episodic memory and associated brain activation differences among early course schizophrenia (n=22), first-degree relatives (n=16) and healthy controls without personal or family history of psychotic disorders (n=28). Study participants underwent functional magnetic resonance imaging on a 3T scanner while performing visual episodic memory encoding and retrieval task. We examined in-scanner behavioral performance evaluating response time and accuracy of performance. Whole-brain BOLD response differences were analyzed using SPM5 correcting for multiple comparisons. There was an incremental increase in response time among the study groups (healthy controls

SUBMITTER: Stolz E 

PROVIDER: S-EPMC3472435 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature