Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time.

ABSTRACT: Cilia are necessary for sonic hedgehog (Shh) signaling, which is required to pattern the neural tube. We know that ventral neural cell fates are defined by a specific cohort of transcription factors that are induced by distinct thresholds of Shh activity mediated by opposing gradients of Gli activator (GliA) and Gli repressor (GliR). Despite this understanding, the role of Shh as an instructive morphogen is viewed as increasingly complex, with current models integrating positive inputs in terms of ligand concentration and time, along with negative feedback via the downstream gene regulatory network. To investigate the relative contributions of the positive and negative inputs from Shh signaling in neural patterning, we took advantage of a protein that uncouples the regulation of GliA and G

SUBMITTER: Su CY 

PROVIDER: S-EPMC3472586 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature