A case-parent triad assessment of folate metabolic genes and the risk of childhood acute lymphoblastic leukemia.

ABSTRACT:

Purpose

We conducted a case-parent triad study evaluating the role of maternal and offspring genotypes in the folate metabolic pathway on childhood acute lymphoblastic leukemia (ALL) risk.

Methods

Childhood ALL case-parent triads (n = 120) were recruited from Texas Children's Hospital. DNA samples were genotyped using the Sequenom iPLEX MassARRAY for 68 tagSNPs in six folate metabolic pathway genes (MTHFR, MTRR, MTR, DHFR, BHMT, and TYMS). Log-linear modeling was used to examine the associations between maternal and offspring genotypes and ALL.

Results

After controlling for the false discovery rate (<0.1), there were 20 significant maternal effects in the following genes: BHMT (n = 3), MTR (n = 12), and TYMS (n = 5). For instance, maternal genotypes for BHMT rs558133

SUBMITTER: Lupo PJ 

PROVIDER: S-EPMC3472623 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature