Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children.

ABSTRACT:

Background

FTO variants are robustly associated with obesity and related traits in many population and shown to have variable impact during life course. Although studies have shown association of FTO variants with adiposity in adult Indian, its association in Indian children is yet to be confirmed.

Methods

Here we examined association of FTO variants (rs9939609 and rs8050136) with obesity and related anthropometric and biochemical traits in 3,126 Indian children (aged 11-17 years) including 2,230 normal-weight and 896 over-weight/obese children. We also compared effects observed in the present study with that observed in previous studies on South Asian adults and children of other ethnic groups.

Results

The variant rs9939609 showed significant association with risk of

SUBMITTER: Dwivedi OP 

PROVIDER: S-EPMC3472993 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature